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Kopp S.J., Daar J., Paulson D.J., Romano F.D., Laddaga R. Effects of oral vanadyl treatment on diabetes-induced alterations in the heart GLUT-4 transporter. vol. Nevertheless, no symptoms of V deficiency in humans have been described yet. Robson R.L., Eady R.R., Richardson T.H., Miller R.W., Jawkins M., Postgate J.R. In: Oguntibeju O., editor. Shigeta S., Mori S., Kodama E., Kodama J., Takahashi K., Yamase T. Yamase T., Ishikawa E., Fukaya K., Nojiri H., Taniguchi T., Atake T. Renirie R., Dewilde A., Pierlot C., Wever R., Hober D., Aubry J.-M. da P.I., Maia S., Pavan F.R., Leite C.Q., Lemos S.S., de Sousa G.F., Batista A.A., Nascimento O.R., Ellena J., Castellano E.E., Niquet E., Deflon V.M. Recently, much attention has been focused on the design of V compounds that can be useful for potential applications as anticancer agents. Rehder D. Implications of vanadium in technical applications and pharmaceutical issues. A few years later, in 2007/08, the same V compound was used in a phase IIa trial in seven type 2 diabetic subjects [180,181] (Fig. Vilter H. Peroxidases from phaeophyceae: a vanadium(V)-dependent peroxidase from, De Boer E., van Kooyk Y., Tromp M.G.M., Plat H., Wever R. Bromoperoxidase from. nearly 150 years after the first discovery of this metal [after 38] (Fig. The ability of this metal to form organometallic compounds has contributed to the increase in the number of studies on the multidirectional biological activity of its various organic complexes in view of their application in medicine. In addition, another study in rats demonstrated V-induced kidney fibrosis [184] at glomerular tuft, preglomeruli, pretubules, and interstitium (cortex and medulla) [185]. One of these compounds exhibited much more potent anti-tumor properties and turned out to be less toxic to normal human cells than the cisplatin complex. Zaporowska H., Wasilewski W. Wpyw wanadu na ukad krwiotwrczy i wybrane wskaniki krwi obwodowej szczurw szczepu Wistar. Metallurgical Examination of a 3-1/4 Thick Armor Plate From a German PzKw V (Panther) Tank; pp. Vol. ). 12). Accessibility In: Ermidou- Pollet S., Pollet S., editors. For this reason, vanadium- and aluminum-free alloys have been introduced for implant applications. This review summarizes recent scientific information on the role and potential use of vanadium in cancer chemoprevention and cancer therapy. Metabolic effects of sodium metavanadate in humans with insulin-dependent and noninsulin-dependent diabetes mellitus. Role of vanadium in nutrition: metabolism, essentiality and dietary consideration. 10 to 100 times higher than the normal intake, affect cholesterol and triglyceride metabolism, influence the erythrocyte shape, and stimulate hepatic glucose oxidation and glycogen synthesis [21]. Many of the reported therapeutic effects are related to the similarity of vanadate and phosphate, thus to the inhibition of the active sites of phosphatases and related enzymes resulting thereof; kinase activation may also be relevant, as well as the ability to generate ROS. Is vanadium of human nutritional importance yet? VVO2-complexes of binucleating bis(dibasic ONS donor ligands) showing activity in vitro on E. histolytica[292]. Czyewska M., Wolska A., wikliska A., Kortas-Stempak B., Wrblewska M. Zaburzenia metabolizmu lipoprotein w zespole metabolicznym. The FER-V and LMMF-V fractions have also been identified in the spleen [108]. It has an atomic number of 23, which means it has 23 protons in its nucleus. As generally accepted, the toxicity of V is dependent on many different factors, including the composition of the diet, type of the V compound (inorganic/organic), nature of ligands attached to V complexes, valence, dose, route of entry of this metal into the organism, duration of action/exposure, and individual and species sensitivity (Fig. Metabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes: Cusi K., Cukier S., DeFronzo R.A., Torres M., Puchulu F.M., Redondo J.C.P. It may also weaken the antioxidant barrier [49,[51], [52], [53]] and intensify lipid peroxidation (LPO) [49,[53], [54], [55], [56], [57], [58]] i.e. 11), which allows glucose molecules to be transported to adipocytes and muscle cells [172], (b) affects the insulin-like growth factor receptor (IGF-IR) by inactivation of associated PTP, (c) activates receptor and non-receptor protein tyrosine kinases (PTK), (d) stimulates glycogenogenesis, and (e) inhibits glycogenolysis and gluconeogenesis [172,173] (Fig. Rehder D. The potentiality of vanadium in medicinal applications. In body fluids and extracellularly, V predominates in the pentavalent form, usually as a vanadate anion (VO3 [152] as based on evidence from animal studies. Fig. 15. Seo K.I., Choi M.S., Jung U.J., Kim H.J., Yeo J., Jeon S.M., Lee M.K. [. Only scarce work has also been reported on vanadium compounds showing activity on certain viruses, bacteria and fungi. It is also used in metallurgical industry for production of steel and non-ferrous alloys [1,9,10]. Based on these findings, the authors suggested a potential role for combination therapy with trace elements in type 2 diabetes mellitus and other insulin-resistant states. Endocrinol. Grill A. Diamond-like carbon coatings as biocompatible materials an overview. Their experiments demonstrated that these complexes acted in an apoptotic mode and were non-toxic to the normal T293 cell line [166]. cibior A., Zaporowska H., Niedwiecka I. Lipid peroxidation in the kidney of rats treated with V and/or Mg in drinking water. For example, in 1987, Meyerovitch and co-investigators [179] reported that V is able to normalize the blood GLU level (in vivo model) (Fig. 7). ACS Symp. 7589. A previous research by the same authors showed that VIVO complexation of galactomannan (GMPOLY), isolated from the lichen Ramalina celastri, exacerbated the cytotoxicity to intracellular Leishmania [9]. Therefore, it would be advisable to shift the balance towards the beneficial action of V, whose pharmacological potential has repeatedly been revealed, as evidenced by the results of many studies conducted in a variety of different cell lines and in animal models. The interactive effects between V and Mg (studied in an animal model) have also been revealed for such parameters as V intake, V absorption, urinary and fecal V excretion, serum Mg and insulin concentration, and insulin resistance index (HOMA-IR) (Fig. More details about these issues along with relevant literature data are provided in sections 8.2.2.5 (anti-cancer), 8.2.2.6 (anti-diabetic), 8.2.2.7 (cardioprotective), 8.2.2.8 (neuroprotective), and 8.2.2.10 (anti-hypercholesterolemic activity). As illustrated on the timeline (Fig. Like Grade 5 titanium, it is also a common choice for dental implants. Careers, Unable to load your collection due to an error. Mechanism of vanadate-induced contraction of airways smooth muscle of the guinea-pig. Oxid. Rodrguez-Lara V., Morales-Rivero A., Rivera-Cambas A.M., Fortoul T.I. In turn, data from another research group [166], who examined the effect of a substituent in the hydrazone ligand of a family of -oxidodivanadium(v) hydrazone complexes on the structure, DNA binding, and anticancer activity, have revealed that V complexes exhibited promising anti-cancer activity against SiHa cervical cancer cells. At low concentrations, V has been found to exert a beneficial effect on the growth and physiological functions of some microorganisms, plants, and fungi. Antunes R.A., Salvador C.A.F., Lopes de Oliveira M.C. Based on available literature data cited in section 4. ACS Symp. They are also essential to improve the understanding of the role of Mg in prevention of V toxicity and clarify the mechanisms underlying the potential protective action of this bioelement in V poisoning. Over the same period, other authors reported that V in the form of vanadate and vanadyl can stimulate GLU oxidation in rat adipocytes [176,177]. 7). ) reaches the gastrointestinal (GI) tract and, in the acidic environment of the stomach, most of the anionic vanadate (absorbed more effectively than VO2+) is transformed into vanadyl (VO2+), precipitated to insoluble vanadyl hydroxides [VO(OH)2] in the slightly alkaline medium of the intestine, and excreted with feces (9498 %) [33,39]. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. the INS receptor), V enhances the effects caused by INS and, consequently, results in INS-R reduction [229]. Vol. Thompson K.H., Lichter J., LeBel C., Scaife M.C., McNeill J.H., Orvig C. Vanadium treatment of type 2 diabetes: a view to the future. Additionally, some V compounds have been reported to be able to counteract tumor metastasis [155]. Effect of age on vanadium nephrotoxicity in rats. 20) are more active than the reference antiamoebic drug Metronizadol (IC50: 29 0.353; 30 0.092; 31 0.85; Metronidazol 1.68M). 7). Vanadium is well-known to be nephrotoxic in vivo. High activity was reported for both enveloped (Herpes simplex) and non-enveloped viruses (Coxsackievirus B4). Vanadium. Key factors affecting the mode of V action. ). However, further studies are needed to explain the exact mechanism(s) accounting for the protective effect of Mg (at the dose used) against the V-induced oxidative stress in the liver. 41. Mohammad A., Wang J., McNeil J.H. cibior A. Wybrane parametry ukadu antyoksydacyjnego szczurw w interakcji wanad-selen oraz wanad-cynk. Vanadium in the form of vanadium oxide is a component in special kinds of steel that is used for automobile parts, springs, and ball bearings. Vanadium microalloying helps you to eliminate process steps and use less energy. 21 13). Kowalski Sz., Ha S., Wyrzykowski D., Zauszkiewicz-Pawlak A., Inkielewicz-Stpniak I. 7). 12). Jacques-Camarena O., Gonzlez-Ortiz M., Martnez-Abundis E., Lpez-Madrueno J.F., Medina-Santilln R. Effect of vanadium on insulin sensitivity in patients with impaired glucose tolerance. To sum up, comprehensive investigations in an animal model on the interactions of V with antioxidant elements, such as Mg or certain compounds with antioxidant properties or dietary/plant-derived antioxidants, are particularly important. cibior A., Adamczyk A., Gobiowska D., Niedwiecka I. Metal interactions affecting the cell metabolism, action of organs and, consequently, the function of the entire organism is still an important issue in toxicology, pharmacology, and medicine. Rosu T., Pahontu E., Ilies D.C., Georgescu R., Mocanu M., Leabu M., Shova S., Gulea A. Sahani M.K., Yadava U., Pandey O.P., Sengupta S.K. cibior A., Zaporowska H. Effects of vanadium(V) and/or chromium(III) on L-ascorbic acid and glutathione as well as iron, zinc, and copper levels in rat liver and kidney. Szafran M., Zakrzewska-Czerwiska J., Jakimowicz D. Bakteryjne topoizomerazy typu I rola biologiczna i zastosowanie jako potencjalnych celw dla antybiotykw. 19). Ferrer E.G., Salinas M.V., Correa M.J., Naso L., Barrio D.A., Etcheverry S.B., Lezama L., Rojo T., Williams P.A.M. Etcheverry S.B., Ferrer E.G., Naso L., Rivadeneira J., Salinas V., Williams P.A. Moreover, there have also been reports on the effect of V administered as BMOV on bioavailability, biochemical parameters in serum, excretion and content of V and Mg in certain internal organs/tissues of healthy rats receiving V-containing feed and varying levels of Mg (magnesium oxide, MgO) [94], and the effect of V (BMOV) on the metabolism and distribution of Mg and some biochemical blood parameters in diabetic rats receiving feed containing V and Mg (MgO) [257]. Sanna D., Serra M., Micera G., Garribba E. Uptake of potential anti-diabetic V. Kiss T., Kiss E., Garribba E., Sakurai H. Speciation of insulin-mimetic VO (IV)-containing drugs in blood serum. Antihypertensive effects of vanadium compounds in hyperinsulinemic, hypertensive rats. cibior A., Adamczyk A., Mroczka R., Niedwiecka I., Gobiowska D., Fornal E. Effects of vanadium (V) and magnesium (Mg) on rat bone tissue: mineral status and micromorphology. 15). In: Nriagu J.O., editor. Magnesium reduces free radical concentration and preserves left ventricular function after direct current shocks. Heyliger C.E., Tahiliani A.G., McNeill J.H. Russanov E., Zaporowska H., Ivancheva E., Kirkova M., Konstantinova S. Lipid peroxidation and antioxidant enzymes in vanadate-treated rats. John Wiley and Sons; New York, Chichester, Weinheim, Brisbane, Singapore, Toronto: 1998. pp. Based on the results obtained, it can be concluded that the issues related to the interactions of V with Mg (as one of the elements with antioxidant potential) are important not only for extending the knowledge of the mechanism of the effect of V on the organism. Pasawska U., Kurzok H., Kiczak L., Bania J. Rola tlenku azotu w regulacji czynnoci ukadu krenia. It has been reported that V in the form of vanadyl (VO2+, tetravalent V4+ state) binds to Tf at the same binding site as the Fe3+ ion [97] and that V5+, for which the cationic form (dioxovanadium cation, VO2 Metal Ions in Biological Systems. 5573. Liu J.C., Yu Y., Wang G., Wang K., Yang X.G. 11). Therefore, once incorporated into the active site of a phosphate-dependent enzyme, taking the place of phosphate, the activity of this enzyme is inhibited, The complex is stable enough to remain intact, and sufficiently lipophilic to slowly cross the cellular membrane, The ligands are detached, oxidation occurs, thus forming H, The ligand system is maintained, or is replaced in part or completely by transferrin to form V. The complex is stable enough to remain intact and contains one or more functions in the outer coordination sphere that are recognized by cell receptors; receptor-mediated uptake is then again a potential transport route. Based on available literature data cited in section 7 and other reports [60,90,91]. It has also been assumed to activate extracellular signal-regulated kinase (ERK) [[211], [212], [213], [214], [215]] (Fig. Other studies suggest that vanadium has no effect on blood sugar levels. Potential carcinogenicity and correlation between the use of VCs and effects on the free-radical cell background are also issues to address. Pessoa J.C., Goncalves G., Roy S., Correia I., Mehtab S., Santos M.F.A., Santos-Silva T. New insights on vanadium binding to human serum transferrin. In a 1996 study published in the medical journal Metabolism, eight people with type 2 diabetes were given . 317345. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Inclusion in an NLM database does not imply endorsement of, or agreement with, Ion pumps as biological targets for decavanadate. 8 Santos M.F.A., Correia I., Oliveira A.R., Garribba E., Costa Pessoa J., Santos-Silva T. Ou H., Yan L., Mustafi D., Makinen M.W., Brady M.J. Nakai M., Watanabe H., Fujiwara C., Kakegawa H., Satoh T., Takada J., Matsushita R., Sakurai H. Sakurai H., Tsuchiya K., Nukatsuka M., Sofue M., Kawada J. Sakurai H., Tsuchiya K., Nukatsuka M., Kawada J., Ishikawa S., Yoshida H., Komatsu M. Takino T., Yasui H., Yoshitake A., Hamajima Y., Matsushita R., Takada J., Sakurai H. Fujimoto S., Fujii K., Yasui H., Matsushita R., Takada J., Sakurai H. Setyawati I.A., Thompson K.H., Yuen V.G., Sun Y., Battell M., Lyster D.M., Vo C., Ruth T.J., Zeisler S., McNeill J.H., Orvig C. Nakano H., Nishioka M., Sangen O., Yamamoto Y. Yasui H., Tamura A., Takino T., Sakurai H. Sakurai H., Watanabe H., Tamura H., Yasui H., Matsushita R., Takada J. PWN; Warszawa: 2013. All those findings gave rise to the following statement: the obtained results can be of concern if in the future, vanadium compounds can be administered in the treatment of diabetic patients [183]. 251279. official website and that any information you provide is encrypted Biochem. 6). The authors proposed the binding of the complexes to a receptor protein that HIV can use to infect T lymphocytes, called chemokine receptor type 4 (CXCR-4), as the mechanism of antiviral action. Biophys. Dudek ., Hryniewicz T., Rokosz K. Zastosowanie tytanu i wybranych stopw tytanu w lotnictwie. Soveid M., Dehghani G.A., Omrani G.R. McDowell L.R. Physiol. 31. 6). Vanadium is sometimes advertised as a sports supplement, but there is no evidence that it boosts performance. Randazzo P.A., Olshan J.S., Bijivi A.A., Jarett L. Cantley L.C., Josephson L., Warner R., Yanagisawa M., Lechene C., Guidotti G. Orvig C., Thompson K.H., Battell M., McNeill J.H. Pandey S.K., Theberge J.F., Bernier M., Srivastava A.K. Ross A., Soares D.C., Covelli D., Pannecouque C., Budd L., Collins A., Robertson N., Parsons S., De Clercq E., Kennepohl P., Sadler P.J. Selected haematological and biochemical parameters of blood in rats after subchronic administration of vanadium and/or magnesium in drinking water. Recently, protective action of pyruvate against V-induced oxidative stress and cytotoxicity has been demonstrated in Chinese hamster ovary (CHO-K1) cells [275]. Fortoul T.I., Rojas-Lemus M. Vanadium as an air pollutant. Domingo J.L., Gmez M. Vanadium compounds for the treatment of human diabetes mellitus: a scientific curiosity? On the other hand, however, many multidirectional studies on V (which has a narrow therapeutic index) have shown that further analyses are still required for this element to be used as a metallodrug in the fight against certain life-threatening modern-age diseases. The average body load of a human individual amounts to 1 mg. In the mammalian host, the Leishmania parasites live inside macrophages. 947, Washington, DC. One of the compounds of this metal, vanadium pentoxide (V2O5), which contains V at the highest oxidation state +5, has been reported to easily reach the alveolar surface, subsequently enter circulation directly, and diffuse in the entire organism inducing diverse injuries [9]. Some preliminary studies have shown encouraging results [1] Deficiency Symptoms In turn, an earlier study conducted by Boscolo et al. Thus, the use of VCs to treat type 2 diabetes is still an open question. The results from this work revealed that V complexes caused cell cycle arrest in the G2/M phase and induced a significant increase in ROS generation in a time- and concentration dependent manner. 6). On this basis, Nielsen and Uthus proposed considering vanadium as an essential trace element for proper growth and development of higher animals [38] In contrast, the essentiality of this metal for humans is unproven (Fig. O: 0.13 %). The total content of V in the organism of adults is about 100200 g (equivalent to the mean tissue concentration of about 40 nM) [6]. Yanardag R., Bolkent S., Karabulut-Bulan , Tunali S. Effects of vanadyl sulfate on kidney in experimental diabetes. Timerbaev A.R., Hartinger C.G., Keppler B.K. sharing sensitive information, make sure youre on a federal food poisoning, gastrointestinal and respiratory infections, typhoid fever, pneumonia, strep throat, tuberculosis, and skin diseases. (Wiley Series in Advances in Environmental Science and Technology). Vanadium is a silvery gray transition metal. If this medicine is taken for a long time, it may become habit-forming (causing mental or physical dependence). ). the free radical process underlying one of the mechanisms of cell damage [50] (Fig. Vol. 13 More recently, VIVO- and VV-complexes of three thiosemicarbazone derivatives (Htsc), [VO(acac)(tsc)] and [VO2(tsc)], were evaluated on the pan-susceptible M. tuberculosis (MTB) H37Rv ATCC 27294 strain. Kiss T., Jakusch T., Bouhsina S., Sakurai H., Enyedy E. Thompson K.H., Liboiron B.D., Sun Y., Bellman K.D.D., Setyawati I.A., Patrick B.O., Karunaratne V., Rawji G., Wheeler J., Sutton K., Bhanot S., Cassidy C., McNeil J.H., Yuen V.G., Orvig C. Costa Pessoa J., Gonalves G., Roy S., Correia I., Mehtab S., Santos M.F.A., Santos-Silva T. Schemberg J., Schneider K., Demmer U., Warkentin E., Mller A., Ermler U. Vilas Boas L.F., Costa Pessoa J. It has been highlighted that the ability of V to accumulate and its strong toxicological potential are an important obstacle limiting the use of this metal in pharmacology. Pessoa J.C. Thirty years through vanadium chemistry. Effect of vanadium on bone metabolism in weanling rats: zinc prevents the toxic effect of vanadium. Anticancer diaminotris(phenolato) vanadium(V) complexes: ligand-metal interplay. 11). 12 Berg L.R. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. 231247. The creatinine clearance was also found to be lowered in the V-supplied rats [183]. Shioda N., Ishigami T., Han F., Moriguchi S., Shibuya M., Iwabuchi Y., Fukunaga K. Activation of phosphatidylinositol 3-kinase/protein kinase B pathway by a vanadyl compound mediates its neuroprotective effect in mouse brain ischemia. V: vanadium, VS: vanadyl sulfate, SMV: sodium metavanadate, NIDDM: noninsulin-dependent diabetes mellitus, IDDM: insulin-dependent diabetes mellitus, Over-W: over-weight, wk: weeks, mo: months. 11), which can lead to intensification of oxidative stress in the cell [49], is highlighted as well. 7). Summary of the mechanisms and factors of vanadium toxicity: vanadium; LPO: lipid peroxidation; ROS: reactive oxygen species; MRC: mitochondrial respiratory chain; OXPHOS: oxidative phosphorylation; M: mitochondrion; Cyt c: cytochrome c; PARP: poly (ADP-ribose) polymerase. 7 Furthermore, V also regulates the activity of key enzymes involved in the phosphorylation and dephosphorylation of proteins, kinases, and phosphatases, taking part not only in carbohydrate and lipid metabolism but also in cell proliferation and differentiation [1,2,4,26,27]. In addition, the examination of the combined V-Mg effects in mammalian organisms may also be helpful for the future safe use of V in medicinal applications. Conversely, intracellularly, it exists mainly in the tetravalent form, as a vanadyl cation (VO2+) (Fig. 15). Nogalska A., wierczyski J. Leptyna hormon o wielu funkcjach. However, all V compounds/complexes (used in these studies) were mainly tested in different cell lines, not in vivo conditions (in an animal model). Pessoa J.C., Garribba E., Santos M.F.A., Santos-Silva T. Vanadium and proteins: uptake, transport, structure, activity and function. Mak I.T., Komarov A.M., Kramer J.H., Weglicki W.B. The word homeopathy comes from the Greek words homios (similar) and pathos (suffering), and the basis of the method is that like . Azay J., Bres J., Krosniak M., Teissedre P.L., Cabanis J.C., Serrano J.J., Cros G. Vanadium pharmacokinetics and oral bioavailability upon single-dose administration of vanadyl sulfate to rats. 17). Ramanadham S., Mongold J.J., Brownsey R.W., Cros G.H., McNeill J.H. In the case of some implants (e.g. VIVO-complexes with the same ligands resulted poorly active. 10 Vanadium (V) is an element with a wide range of effects on the mammalian organism. Evangelou A.M. Vanadium in cancer treatment. Kom. Most data in this area were obtained in in vitro studies of the influence of V on human immunodeficiency HIV-1/HIV-2 virus [33]. Vanadium and Its Role in Life). [126], (c) inhibition of the activity of acid phosphatase (SAcP) (Fig. Zabolotny J.M., Haj F.G., Kim Y.B., Kim H.J., Shulman G.I., Kim J.K., Neel B.G., Kahn B.B. However, the discovery was not attributed to him. Among the mechanisms of the anti-fungal activity of V complexes which, likewise the mechanisms of the anti-bacterial and anti-viral activity of this metal have not been fully recognized yet, interactions with DNA by intercalation have been proposed [133]. In: Fortoul T.I., Avila-Costa M.R., editors. Schmidt H., Andersson I., Rehder D., Pettersson L. Mehtab S., Gonalves G., Roy S., Tomaz A.I., Santos-Silva T., Santos M.F.A., Romo M.J., Jakusch T., Kiss T., Costa Pessoa J. Delgado T.C., Tomaz A.I., Correia I., Costa Pessoa J., Jones J.G., Geraldes C.F., Castro M.M. Additionally, still not much is known regarding global toxicity issues and effects of VCs on the immune system and inflammatory reactions, particularly if long-term administration is required. vanadyl sulfate - VOSO4, VS; sodium metavanadate - NaVO3, SMV; sodium orthovanadate - Na3VO4) were used as potential antidiabetic drugs has been constantly growing. Studies carried out so far on V have shown that the bioactive complexes/compounds of this metal can be therapeutically active at low concentrations [1,2]. The mechanisms of immune response upon V exposure should also be better clarified. Donaldson J., Hemming R., LaBella F. Vanadium exposure enhances lipid peroxidation in the kidney of rats and mice. As shown in Fig. As presented in another subsection of this paper, V is part of metallic biomaterials (mainly titanium alloys), bioactive coatings (including polymeric coatings), and diamond-like layers applied to the surface of some titanium alloys in order to increase the bioactivity of implants and improve osseointegration [11].
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