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Its an ingredient whose safety hasnt been questioned so far by anyone (at least not that we know about). The release profiles of the VC-IP from SBA-15 and -cyclodextrin compared to the dissolution of pure VC-IP are shown in. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating. Common concerns See how this product scores for common concerns. Liu X, Grice JE, Lademann J, Otberg N, Trauer S, Patzelt A, Roberts MS. Br J Clin Pharmacol. Other than helping oil and water to blend, the main thing of Olivem 1000 is generating liquid crystal structures that are similar to the lipid structures of the stratum corneum (the outermost layer of the skin). Tetrahexyldecyl Ascorbate | CosDNA It looks similar to the blueberry but is even darker and the berries do nottaste nice and yummy but are rather sour. Unable to load your collection due to an error, Unable to load your delegates due to an error. Life (Basel). As for its fatty acid profile, it contains 48-59% barrier-repairing linoleic acid, 17-30% nourishing oleic acid and also some (4.5-11%) potentially anti-inflammatory linolenic acid. ; Lima, C.R.R.C. National Library of Medicine This strategy could allow the easy dispersion of the active ingredient both in water and oil phases of semisolid formulations, as well as allow its direct use in compacts and other solid formulations for color cosmetic applications. Friday_lover07 2021-03-09 And we are still not done, as Bakuchiol shows not only anti-aging properties but also nice anti-acneeffects. ; Quenca-Guillen, J.S. All release experiments showed good reproducibility. It leaves a nice non-greasy, non-heavy feeling on the skin. Thanks to this, Olivem 1000 doubles as an active ingredient with significant moisturizing, barrier-repairing and soothing properties. We could find Tetrahexyldecyl Ascorbate mentioned only in one publishedin-vivo study that examined the anti-aging properties of a silicone formula containing 10% AA and 7% THDA. The authors theorized that the 10% AA is released slowly from the silicon delivery system and probably stays in the upper layer of the skin to give antioxidant benefits, while THDA penetrates more rapidly and deeply and gives some wrinkle-reducing benefits. Couple of other studies show that FA just by itself is also a nice addition to cosmetic formulations: itcan penetrate the skin (which is kind of important to do the job) and it has protecting properties against UV caused skin damage. Ethanol was provided by Applichem Panreac (Darmstadt, Germany) and VC-IP by Nikkol Group (Tokyo, Japan). A double-blind, randomized placebo-controlled clinical efficacy study was conducted on 60 female subjects aged 20-30 years with skin changes related to photoaging and without photoprotective habits. A Feature Third, THDA seems to have all three magic abilitiesof pure vitamin C: it gives antioxidant protection from both UVB and UVA rays, it increases collagen synthesis (even more than AA) and it has askin brightening effect by reducing melanogenesis by more than 80% in human melanoma cell cultures. The site is secure. At first glance, it seems like your average emollient plant oil: it looks like an oil and it's nourishing and moisturizing to the skin but if we dig a bit deeper, it turns out that jojoba oil is really special and unique: technically - or rather chemically - it's not an oil but awax ester (and calling it an oil is kind of sloppy). Mixes well with most creams or lotions. Overall, Aronia Melanocarpa is a potent antioxidant berry that's nice to spot on the ingredient list. On the other hand, a more recent study from 2015 found that beta-arbutin is more effective both on mouse melanoma cells and onhuman melanoma cells (btw, kojic acid was the most effective on human melanoma cells). Mixes well with most creams or lotions. Vitamin C Tetraisopalmitate, The https:// ensures that you are connecting to the Ascorbyl Tetraisopalmitate is more stable and has. It is approved for use as a food additive in the EU, [1] the U.S., [2] Canada, [3] Australia, and New Zealand. The .gov means its official. Free U.K. shipping for orders over 60. Bagchi, D.; Garg, A.; Krohn, R.; Bagchi, M.; Tran, M.X. ; Van Schaftingen, E. Vitamin C Biosynthesis, recycling and degradation in mammals. The extract coming from the dark colored berry calledblack chokeberry. ; Kwon, O.-S.; Song, S.; Chung, Y.-B. The study was a small (10 patients), double-blind experiment,and the formula did show some measurable anti-aging results. Feature papers are submitted upon individual invitation or recommendation by the scientific editors and must receive We are massive vitamin C fans and have written about it inexcruciating detail. Vitamin C inhibits the activation of the enzyme tyrosinase, which prevents the overproduction of melanin and helps to control and treat hyperpigmentation. Thus, the objective of the present study was to evaluate the clinical efficacy of sunscreens and cosmetic formulations containing ascorbyl tetraisopalmitate and rice peptides for the improvement of skin photoaging in young women. This means the ingredient has proven efficacy in a specific claim category which has been recognized and approved by the corresponding government agencies. https://doi.org/10.3390/cosmetics4030021, Bastianini, Maria, Michele Sisani, and Annarita Petracci. All the authors has contributed equally to the development of the article. Finally, the dispersion was filtered using a 0.20-m pore size filter. 2001;14 Suppl 1:23-7. doi: 10.1159/000056386. Ascorbyl Tetraisopalmitate is a tetraester of Ascorbic Acid (q.v.) Chemically, a wax ester is a fatty acid + a fatty alcohol, one long molecule. A differential view. Its a humectant meaning that it can help the skin to attract water and then hold onto it. This means the ingredient has proven efficacy in a specific claim category which has been recognized and approved by the corresponding government agencies. Disclaimer. In spite of this, if you search for "hyaluronic acid vs sodium hyaluronate" you will find on multiple places that sodium hyaluronate is smaller and can penetrate the skin better. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Author to whom correspondence should be addressed. BG is approved by Ecocert and is also used enthusiastically in natural products. The .gov means its official. Ascorbic acid is connected with four 14-Methylpentadecanoic acids ( tetraester ), making the water-soluble molecule lipophile ( oil-soluble) that can easily penetrate through the skin's lipid barrier, enhancing delivery and effectiveness. 2005 Mar 3;291(1-2):21-9. doi: 10.1016/j.ijpharm.2004.07.039. For the pure VC-IP, the maximum release is about 40%. The inclusion method produced a homogeneous white powder sample. The VC-IP powder was white and showed a very high stability, opening new possibilities for the application of this active ingredient. Its special thing is being an osmolyte, a molecule that helps to control cell-water balance. Darr, D.; Combs, S.; Dunston, S.; Manning, T.; Pinnell, S. Topical vitamin C protects porcine skin from ultraviolet radiation-induced damage. Form of Vitamin C, THDA;Tetrahexyldecyl Ascorbate. With thiscontext in mind let's see what THDA might be able to do. Research also shows that it might be useful for wound healing as it promotes fibroblast (nice type of cells in our skin that produce skin-firming collagen) proliferation. In addition,vitamin C's three magic properties (antioxidant, collagen booster, skin brightener) are all properly proven in-vivo (on real people), but for the derivatives, it's mostly in-vitro studies or in thecase of THDA, it's in-vitro and done by an ingredient supplier. In order to verify the effective formation of cyclodextrin/VC-IP complex, XRPD analysis on the sample was carried out (, In order to determine the exact content of VC-IP in the sample, the active ingredient was extracted from the hybrid by sonication treatment in ethanol and the obtained solution was analyzed by HPLC [. So being a wax ester results in a couple of unique properties: First, jojoba oil is extremely stable. Photoprotective formulations containing substances with antioxidant properties in combination have been used as a strategy for the improvement of photoaged skin conditions. It is part of the popular emulsifier trade named Olivem 1000 that is well-known for generating biomimeticliquid crystal structures. The EWG VERIFIED mark means a product meets EWGs strictest criteria for transparency and health. It works over a very wide pH range (3-12)and can be used to thicken up low-ph formulas, such as exfoliants. There is also research showing that panthenol can help our skin to produce more lovely lipids that are important for a strong and healthy skin barrier. BGs main job is usually to be a solvent for the other ingredients. HHS Vulnerability Disclosure, Help 2012. So this all sounds really great, but these are only in-vitro results at this point. JUMISO All Day Vitamin VC-IP 1.0 Firming Serum. A products hazard score is not an average of the ingredients hazard scores. "Ascorbyl Tetraisopalmitate Inclusion into -Cyclodextrin and Mesoporous SBA-15: Preparation, Characterization and In Vitro Release Study" Cosmetics 4, no. If HA does not tell you anything we have a super detailed, geeky explanation about it here. sharing sensitive information, make sure youre on a federal There is also in-vitro data showing that it converts to AA in the skin. Another advantage of squalane is that it is pretty much compatible with all skin types and skin conditions. Int J Pharm. Ascorbyl Tetraisopalmitate | Oil-soluble form of Vitamin C | Ingredient Please enable it to take advantage of the complete set of features! This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply. An. Cosmetics 2017, 4, 21. Bookshelf (2017) Introduction to skin aging. It requires a low pH to penetrate the skin, but this cannot be tolerated by everyone. Italso acts as a thickening and gelling agent thatcreates nice, non-sticky and supple textures. fragrance, preservatives or chemical sunscreens) in the product. Nanoscale. A vitamin C derivative, ascorbyl tetraisopalmitate (ATIP) is thetetraester of ascorbic acid and isopalmitic acid. Sunscreens and Cosmetic Formulations Containing Ascorbyl Tetraisopalmitate and Rice Peptides for the Improvement of Skin Photoaging: A Double-blind, Randomized Placebo-controlled Clinical Study Photochem Photobiol. An official website of the United States government. Unless you are a gimme-the-newest-shiny-thing-under-the-sun-type. It's often combined with another emollient calledCoco-Caprylate/Caprate and the two together can serve as a great replacement for some volatile silicones, likeCyclopentasiloxane. Photobiol. Unable to load your collection due to an error, Unable to load your delegates due to an error. Enriched with Bakuchiold to provide extra anti-aging. https://doi.org/10.3390/cosmetics4030021, Bastianini M, Sisani M, Petracci A. Ascorbyl Tetraisopalmitate Inclusion into -Cyclodextrin and Mesoporous SBA-15: Preparation, Characterization and In Vitro Release Study. [4] It's also a solvent and can boost the effectiveness of preservatives. Third, jojoba oil moisturizes the skin through a unique dual action:on the one hand, it mixes with sebum and forms a thin, non-greasy, semi-occlusive layer; on the other hand, it absorbs into the skin through pores and hair follicles thendiffuses into the intercellular spaces of the outer layer of the skin to make it soft and supple. positive feedback from the reviewers. Chemically speaking, it is a saturated (no double bonds) hydrocarbon (a molecule consisting only of carbon and hydrogen), meaning that it's a nice and stable oily liquid with a long shelf life. In order to be human-readable, please install an RSS reader. At first glance, you could think that Bakuchiol is your average plant extract. 2022 Sep 13;10(9):2266. doi: 10.3390/biomedicines10092266. On balance, the point is this: in contrast to real plant oils, wax esters were designed by Mother Nature to stay on the surface and forma protective, moisturizing barrier and jojoba oil being a wax ester is uniquely excellent at doing that. NIKKOL VC-IP | Nikko Chemicals - India | NIKKOL GROUP Would you like email updates of new search results? 2023 Feb 18;13(2):579. doi: 10.3390/life13020579. (Many plant oils tend to go off pretty quickly). The results showed that the daily use of the formulations under study improved the skin conditions by increasing skin hydration and dermis echogenicity. Ascorbic acid or vitamin C is a strong antioxidant widely used in cosmetic and food fields. Careers. If you are not a daredevil-type who doesn't want to stop using a super well-proven retinol for a newbie like Bakuchiol, we have good news. Ascorbic acid is extremely sensitive to heat and light and it oxidizes very quickly. [4], Ascorbyl palmitate is also marketed as "vitamin C ester". Please try again later! To solve this problem they came up with vitamin C derivatives, and one of them is Tetrahexyldecyl Ascorbate (let's call it THDA in short). Ascorbyl tetra-2-hexyldecanoate. Various types of drug carriers were studied and considered in order to support VC-IP and obtain the conversion in powder. 2017. This does not mean thatascorbyl palmitate cannot penetrate the skin (because it can, it's oil soluble and the skin likes to absorb oil soluble things) but this means that it's questionable ifascorbyl palmitate can be converted into pure Vit C in the skin. Even if you heat it to 370 C (698 F) for 96 hours, it does notbudge. It's the salt form of famous humectant and natural moisturizing factor, hyaluronic acid. So now, you know that Vitamin C is great and all, but it's really unstable and gives cosmetics companies many headaches. The white homogeneous powder obtained was characterized by TGA, DSC, HPLC, and FE-SEM. Wang, S. Ordered mesoporous materials for drug delivery. Copyright 2016 Elsevier Ltd. All rights reserved. In other words, it's a superb moisturizer that makes your skin nice and smooth, withoutbeing heavy or greasy. Third, another study that wanted to examine the antioxidant properties of AP was surprised to find that even though AP does have nice antioxidant properties;following UVB radiation (the same one that comesfrom the sun) it also promotes lipid peroxidation and cytotoxicity. NLM (National Library of Medicine). Thanks! It is derived from the seeds ofPsoralea Corylifolia, aka Babchi,aplant important in Indian and Chinese medicine. As far as skincare goes, sodium hyaluronate and hyaluronic acid are pretty much the same and the two names are used interchangeably. The https:// ensures that you are connecting to the Ascorbyl Tetraisopalmitate is an oil-soluble derivative of Vitamin C that can be used in higher.

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